HF - ACEI

Table 1. Comparison of ACEI (Those with FDA approved for heart failure treatment)

ACEI
Accupril

Altace

Capoten

Mavik

Monopril

Prinivil

Vasotec

Zestril

Generic name
Quinipril

Ramipril

Captopril

Trandola
pril

Fosino
pril

Lisinopril

Enalapril

Lisino
pril

FDA Indications
HTN, CHF

HTN, CHF

HTN, CHF, Asymp LV dysfunction

HTN,
S/P MI CHF

HTN, CHF

HTN, CHF

HTN, CHF, Asymp LV dysfunction

HTN, CHF

Tablet Size
5, 10, 20, 40

1.25, 2.5. 5, 10

12.5, 25, 50, 100

1, 2, 4

10, 20

5, 10, 20, 40

2.5, 5, 10, 20

5, 10, 20, 40

Starting Dose
5 mg bid

1.25-2.5 mg qd

6.25-12.5 mg tid

1 mg qd

5 mg qd

2.5-5 mg qd

2.5 mg bid

2.5-5 mg qd

Target Dose (a)
20 mg bid

10 mg qd

50 mg tid

2-4 mg qd

20 mg qd

20 mg qd

10 mg bid

20 mg qd

Maximum Dose
40 mg bid

10 mg bid

100 mg tid

8 mg qd

40 mg qd

40 mg qd

20 mg bid

40 mg qd

(a) = average maintenance dose used in clinical trials
Tablets are in all forms and sizes. Many of them can be cut in a half with good pill cutter. It may save money in many preparations and dosages.
Comparison of ACEI. Drug Formulary and Pricing

Brand Name

Generic

Medica
(2002)

BCBS
(2002)

UCare
(2002)

Pref
One
(2002)

Health
Partner

Mayo
(2002)

Aetna
(2002)

PCS
(2002)

Dose/Day
(mg)

Cost/30 Days
($)
..............

Accupril (a)
Quinapril

Y

.

Y

Y

.

Y

Y

Y*

5 bid
10 /day
10 bid
20 /day
20 bid
40/day
40 bid

64.00
31.79
63.58
31.79
63.58
31.79
63.55

Altace
Ramipril

.

Y

.

Y

.

Y

Y

Y*

2.5/day
5/day
10/day
10 bid

31.21
33.70
38.45
76.90

Capoten
Captopril

Y (G)

Y (G)

Y

Y (G)

Y

Y (G)

Y (G)

Y (G)*

25 tid
50 tid
100 tid
150 tid

14.03 (G)
19.25 (G)
25.52 (G)
32.56 (G)

Mavik (a)
Trandola
pril

.

.

.

.

.

Y

.

Y

1/day
2/day
4/day
4 bid

27.32
27.32
27.32
54.65

Monopril (a)
Fosinopril

.

.

Y

.

.

Y

.

Y

10/day
20/day
20 bid
40/day

30.50
30.50
60.98
30.50

Prinivil
Lisinopril

Y

Y

.

.

Y

.

Y

.

10/day
20/day
40/day

29.10
31.14
47.33

Vasotec
Enalapril

Y (G)

Y (G)

.

.

.

Y (G)

Y

Y (G)

5 bid
10 bid
20 bid

34.27 (G)
35.34 (G)
50.28 (G)

Zestril
Lisinopril

.

Y (G)

Y

Y

.

Y

.

Y*

10/day
20/day
40/day

30.97
30.97
47.33

* = Preferred agent in classification, (a) = No price different at higher strength tablet, (G) = Generic

ACEI	Accupril	Altace	Capoten	Mavik	Monopril	Prinivil	Vasotec	Zestril
Generic name	Quinipril	Ramipril	Captopril	Trandola pril	Fosino pril	Lisinopril	Enalapril	Lisino pril
FDA Indications	HTN, CHF	HTN, CHF	HTN, CHF, Asymp LV dysfunction	HTN, S/P MI CHF	HTN, CHF	HTN, CHF	HTN, CHF, Asymp LV dysfunction	HTN, CHF
Tablet Size	5, 10, 20, 40	1.25, 2.5. 5, 10	12.5, 25, 50, 100	1, 2, 4	10, 20	5, 10, 20, 40	2.5, 5, 10, 20	5, 10, 20, 40
Starting Dose	5 mg bid	1.25-2.5 mg qd	6.25-12.5 mg tid	1 mg qd	5 mg qd	2.5-5 mg qd	2.5 mg bid	2.5-5 mg qd
Target Dose (a)	20 mg bid	10 mg qd	50 mg tid	2-4 mg qd	20 mg qd	20 mg qd	10 mg bid	20 mg qd
Maximum Dose	40 mg bid	10 mg bid	100 mg tid	8 mg qd	40 mg qd	40 mg qd	20 mg bid	40 mg qd

Brand Name	Generic	Medica (2002)	BCBS (2002)	UCare (2002)	Pref One (2002)	Health Partner	Mayo (2002)	Aetna (2002)	PCS (2002)	Dose/Day (mg)	Cost/30 Days ($) ..............
Accupril (a)	Quinapril	Y	.	Y	Y	.	Y	Y	Y*	5 bid 10 /day 10 bid 20 /day 20 bid 40/day 40 bid	64.00 31.79 63.58 31.79 63.58 31.79 63.55
Altace	Ramipril	.	Y	.	Y	.	Y	Y	Y*	2.5/day 5/day 10/day 10 bid	31.21 33.70 38.45 76.90
Capoten	Captopril	Y (G)	Y (G)	Y	Y (G)	Y	Y (G)	Y (G)	Y (G)*	25 tid 50 tid 100 tid 150 tid	14.03 (G) 19.25 (G) 25.52 (G) 32.56 (G)
Mavik (a)	Trandola pril	.	.	.	.	.	Y	.	Y	1/day 2/day 4/day 4 bid	27.32 27.32 27.32 54.65
Monopril (a)	Fosinopril	.	.	Y	.	.	Y	.	Y	10/day 20/day 20 bid 40/day	30.50 30.50 60.98 30.50
Prinivil	Lisinopril	Y	Y	.	.	Y	.	Y	.	10/day 20/day 40/day	29.10 31.14 47.33
Vasotec	Enalapril	Y (G)	Y (G)	.	.	.	Y (G)	Y	Y (G)	5 bid 10 bid 20 bid	34.27 (G) 35.34 (G) 50.28 (G)
Zestril	Lisinopril	.	Y (G)	Y	Y	.	Y	.	Y*	10/day 20/day 40/day	30.97 30.97 47.33