Management of Acute Myocardial Infarction at St Cloud Hospital.
1999Data from National Registry of Myocardial Infarction 3 (NRMI 3)
- Covered memo
- Summery result
- Direct admission
- Dermographic, clinical presentation
- Treatment/ Interventional/ Initial reperfusion, clinical presentation (IV thrombolysis, primary PTCA), length of stay, mortality
- Primary PTCA/ procedures, procedures performed prior to discharge
- Clinical events (All patients, IV thrombosysis, primary PTCA, no initial reperfusion)
- Medications received within 24 hours (All patients, IV thrombolysis, primary PTCA, no initial reperfusion)
- Discharged medications/therapies (All patients, IV thrombolysis, primary PTCA, no initial reperfusion)
- Primary PTCA
- Transfer-In
- Thrombolysis at 1st hospitals, initiated at registry hospital, length of stay and clinical events
- Medications received within 24 hours, discharged medications/therapies from registry hospital, procedures performed prior to discharge
- Primary PTCA - dermographic, clinical presentation, length of stay and clinical events
- Primary PTCA - medications received within 24 hours, discharged medications/therapies from registry hospital, primary PTCA patients receiving procedures prior to discharge.
DATE:TO: CMHC, ETU, CCU/ICU, Telemetry Unit, Cardiac Catheterization Laboratory.
FROM: Pradub, Sukhum, M.D, Susan Heynig, R. N.
RE: Acute Myocardial Management at SCH in 1999, a NRMI 3 Report.
This is the third consecutive year report for acute myocardial infarction management at SCH, which was started since 1997. It was generated from National Registry of Myocardial Infarction phase 3 (NRMI 3) data, which CMHC and SCH has been participating along with large number of centers and hospitals in the United States.
Again, CMHC-SCH continued to practice with Primary PTCA as the initial reperfusion therapy of choice, over the IV Thrombolysis.
With subsequent years, the report has increased the detail. This year report appears overwheming and the reader may have to search for the areas of particular interest. Below is the guidelines and comments to assist viewing this report:
I. Comparison is best with "Like Hospitals" (LH), with the same size and cardiologic services to SCH (251-350 beds with interventional and open heart surgery procedures). The "Minnesota Hospitals" (MN) and "Nation Hospitals" (Nation) result are from all hospitals with different cardiologic services capability.
II. There are two major patient categories: Direct admission catagory and transfer-In catagory (transfer from other less cardiologic services capability hospitals), each has its own statistics. The transfer-In patient has less detail. Note that SCH transfer-In is just barely more than 50%, some what higher than "LH", "MN" and "Nation". The total acute myocardial infarction has continued to increase for the past 3 years.
III. Primary PTCA is displayed separately as in previous year report, but this year it is also included in both Direct Admission and Transfer-In sections for better comparison with other type of therapy.
IV. SCH performed initial reperfusion treatment of the "eligible" patient at higher percentage than other centers this year. All of them were treated with primary PTCA (except one patent who was treated with IV thrombolysis). The result (ie. door to dilatation time or mortality rate of the Primary PTCA treatment group) should not come from "selected" patient.
V. Mortality rate of the ("non selected") Primary PTCA treatment patients is significantly less than other centers in the past 3 years.
VI. Door to dilatation time (median, minute) is significantly lower than other centers. Note that procedure performed during 7 am through 11pm was within 68 minutes while those during 11 pm through 7 am and during weekend was up to 102 minutes.
VII. Utilization of medications at St Cloud Hospital continues to be more appropriated, compare to other centers, for the past 3 years. Similar to the past years, we performed less CABG, more noninvasive, and not more total coronary angiographic procedures.
Acute Myocardial Infarction Management at SCH in 1999(a), summery result.
(Result from NRMI 3)
SCH Like Hospital
(153 Centers)(b) MN
(Centers)
(c) Nation
(1505 Centers)
(c)TOTAL PATIENTS 535 32820 5178 20619Direct Admission 261 49% 20960 64% 74% 77%Transfer-In 274 51% 11860 36% 26% 23%DIRECT ADMISSION 261 20960 3842 159588Primary PTCA 56 21% . 16% 9% 9%IV Thrombolysis 1 0.4% . 13% 15% .18%Neither 204 78% . 71% 76% 74%TRANSFER-IN 274 11860 1336. 46531.Primary PTCA 10 . . . . 2628IV Thrombolysis at 1st Hospital 83 30% . . 26% 27%IV Thrombolysis at Registry Hospital 0 0% . 1% 0% 2%(a) - NRMI 3 (1/1/99 - 12/31/99).
(b) - Like Hospital = 251-350 beds with Interventional, Open heart surgery.
(c) - Large number but not all hospitals in MN or in Nation participated.
St Cloud Hospital Direct Admission, 1999.
SCH
(261/535)
(49%) Like Hospital
(20960)(64%) MN
(3842)
(74%) Nation
(159588)
(77%)DERMOGRAPHIC . Male 168 64% . 61% 58% 59%Female 93 36% . 39% 42% 41%Age (mean years) 71 . 69 . 70 69- Male 68 . 66 . 67 66- Female 75 . 73 . 75 74CLINICAL PRESENTATION .Sx to door (median minutes) 165 . 125 . 127 125Chest pain at presentation 156 60% . 66% 58% 63%ST elevation and/or LBBB on 1st 12-lead EKG 67 26% . 39% 32% 39%Pre-existing CV disease 72 28% . 41% 43% 41%Diabetes mellitus 62 24% . 29% 28% 30%< 68 years 65 25% . 26% 28% 27%No CHF (Killip 1) 192 74% . 75% 75% 73%Rales, JVD (Killip 2) 51 20% . 15% 17% 17%Pulmonary edema (Killip 3) 17 7% . 8% 7% 8%Cardiogenic shock (Killip 4) 1 0% . 2% 1% 1%Back to top
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St Cloud Hospital Direct Admission, 1999. (continue)
SCH
(261/535)
(49%) Like Hospital
(20960)(64%) MN
(3842)
(74%) Nation
(159588)
(77%)TREATMENT/ INTERVENTIONAL/
INITIAL REPERFUSION
. Eligible patients for initial reperfusion (a) 48/261 18% . 23% 19% 20%Treat eligible patients 42/48 88% . . . .Treat uneligible patients . 13% . 23% 21% 26%CLINICAL PRESENTATION .IV thrombolysis 1/261 . . . . .Sx to door (median minutes) 135 . 90 . 95 90Door to data (median minutes) 14 . 7 . 7 7Data to decision NA . 16 . 13 15Dicission to drug NA . 10 . 11 8Door to drug 58 . 35 . 31 34Door to drug <30 minutes . . . 43% 49% 45%Primary PTCA 56/261 . . . . .Sx to door (median minutes) 109 . 90 . 95 93Door to data 8 . 7 . 7 7Data to dilatation 65 . 101 . 80 96Door to dilatation(b) 73 . 108 . 85 104- From 7 am to 11 pm (33) (c) 68 . . . . 97-107- From 11 pm to 7 am and during weekend (22) (c) 102 . . . . 120Door to dilatation <90 minutes . 65% . 34% 56% 34%LENGTH OF STAY
(median, mean days) .All patients 4.2, 5.6 . 4.9, 6.4 . 4.2, 5.6 4.2, 5.5IV thrombolysis . . 4.8, 5.9 . 3.5, 4.2 3.3, 4.0Primary PTCA 3.6, 4.5 . 3.9, 5.1 . 3.7, 5.0 3.9, 5.1No reperfusion 4.5, 5.9 . 5.1, 6.7 . 4.4, 5.9 4.6, 6.0MORTALITY .All patients 27/261 10.3 . 10.5% 9.8% 10.3%IV thrombolysis 0/1 . . 6.9% 5.3% 5.2%Primary PTCA 0/56 0% . 5.7% 5.9% 6.0%No reperfusion 27/204 13.2% . 12.2% 11.1% 12.0%(a) - Patients with ST elevation in >2 leads and/or LBBB on 1st 12 lead ECG, MI Sx onset <12 hours.
(b) Patients with no chest pain at presentation has longer door to dilatation time.
(c) In parenthesis represents number of patients.Back to top
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St Cloud Hospital Direct Admission, 1999. (continue)
SCH
(261/535)
(49%) Like Hospital
(20960)(64%) MN
(3842)
(74%) Nation
(159588)
(77%)PRIMARY PTCA/ PROCEDURES
. PTCA without stent 5/56 9% . 19% 10% 17%PTCA with stent . 91% . 71% 76% 73%IV Activase and PTCA 0 . . 3% 9% 3%IC lytic 0 . . 0.4% 0% <1%Spontaneous reperfusion 0 . . 2% 1% 2%Immediate CABG 0 . . 4% 4% 5%PROCEDURES PERFORMED PRIOR TO DISCHARGE .Total coronary angiography 185/261 71% . 81% 43% 50%Primary PTCA 56 21% . 16% 9% 9%- Without stent . 9%* . 19%* 14% 17%- With stent . 91% . 71% 76% 73%Coronary angiography (a) 94 36% . 41% 18% 29%PTCA 35 13% . 24% 16% 12%- Without stent 1 0.4% . 4% 2% 2%- With stent 34 13% . 20% 14% 10%CABG 20 8% . 12% 6% 6%- Immediate/primary PTCA 0 . . 5% 4% 5%- Immediate/all direct admission 0 . . 1% . .IABP 16 6% . 6% 4% 3%Echocardiography 143 55% . 48% 59% 51%Stress test 42 16% . 8% 12% 9%(a) This category does not include procedures relate to Primary PTCA
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St Cloud Hospital Direct Admission, 1999. (continue)
SCH
(261/535)
(49%) Like Hospital
(20960)(64%) MN
(3842)
(74%) Nation
(159588)
(77%)CLINICAL EVENTS . All patients 261 . 20960 . 3842 159588Free of adverse outcome 192 74% . 50% 43% 51%Recurrent MI 7 3% . 2% 2% 2%Major bleeding 0 0.0% . 3.8% 2.5% 2.6%Stroke 4 1.5% . 1.0% 1.3% 1.0%IC hemorrhage 0 0.0% . 0.2% 0.1% 0.2%Thromboembolic 3 1.1% . 0.5% 0.8% 0.4%IV thrombolysis 1 . 2701 . 562 28036Free of adverse outcome 1 . . 50% 42% 52%Recurrent MI . . . 3% 3% 3%Major bleeding . . . 4.9% 2% 2.6%Stroke . . . 1.4% 1.6% 1.3%IC hemorrhage . . . 0.9% 0.2% 0.8%Thromboembolic . . . 0.3% 0.4% 0.2%Primary PTCA 56 . 3326 . 355 13681Free of adverse events 49 88% . 56% 54% 56%Recurrent MI 1 2% . 1% 1% 1%Major bleeding 0 0% . 4.7% 4.8% 4.6%Stroke 0 0% . 0.4% 0.8% 0.7%IC hemorrhage 0 0% . 0.1% 0% 0.1%Thromboembolic 0 0% . 0.3% 0.8% 0.4%No initial reperfusion 204 . . . . .Free of adverse events 142 70% . 49% 42% 50%Recurrent MI 6 3% . 2% 1% 1%Major bleeding 0 0% . 3.3% 2.3% 2.4%Strroke 4 2.0% . 1.1% 1.3% 1.0%IC hemorrhage 0 0% . 0.1% 0.1% 0.1% Thromboembolic 3 1.5% . 0.6% 0.8% 0.5%Back to top
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St Cloud Hospital Direct Admission, 1999. (continue)
SCH
(261/535)
(49%) Like Hospital
(20960)(64%) MN
(3842)
(74%) Nation
(159588)
(77%)MEDICINES RECEIVED WITHIN 24 HOURS . All patients 261 20960 3842 159588ASA 240 92% . 85% 87% 83%Beta blocker 170 65% . 52% 59% 54%ACE inhibitor 90 34% . 23% 29% 24%IIb/IIIa 61 23% . 21% 17% 13%Heparin 141 54% (a) . 79% 76% 72%Calcium channel blocker (b) 32 12% . 13% 16% 13%IV thrombolysis 1 2701 562 28036ASA . . . 96% 97% 94%Beta blocker . . . 66% 71% 67%ACE inhibitor . . . 19% 21% 19%IIb/IIIa . . . 18% 12% 9%Heparin . . . 97% 96% 96%Calcium channel blocker . . . 5% 3% 4%Primary PTCA 56 3326 355 13681ASA 55 98% . 92% 96% 91%Beta blocker 38 68% . 56% 69% 58%ACE inhibitor 18 32% . 19% 30% 20%IIb/IIIa 52 93% . 67% 76% 67%Heparin 39 70% (a) . 91% 89% 91%Calcium channel blocker 1 2% . 9% 15% 8%No initial reperfusion 204 14933 2925 117871ASA 184 90% . 82% 84% 80%Beta Blocker 131 64% . 48% 56% 51%ACE inhibitor 72 35% . 25% 30% 25%IIb/IIIa 9 4% . 11% 10% 8%Heparin 101 50% (a) . 73% 71% 71%Calcium channel blocker 31 15% . 16% 18% 15%(a) Patients undergoing primary PTCA who recieved GPIIbIIIa were not included.
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St Cloud Hospital Direct Admission, 1999. (continue)
SCH
(261/535)
(49%) Like Hospital
(20960)
(64%) MN
(3842)
(74%) Nation
(159588)
(77%)DISCHARGED MEDICATIONS/ THERAPIES .All patients 229 . 17969 . 2722 101295ASA 207 90% . 82% 83% 77%Beta blocker 185 81% . 63% 69% 63%ACE inhibitor 139 61% . 39% 47% 41%Lipid lowering agent 120 52% . 35% 42% 33%Female HRT (female only) . 12% . 10% 12% 8%Smoke cessation advice to smokers . 29% . 43% 53% 40%IV thrombolysis 1 . 2333 . 302 12121ASA . . . 90% 89% 87%Beta blocker . . . 74% 76% 75%ACE inhibitor . . . 37% 46% 40%Lipid lowering agent . . . 42% 58% 43%Female HRT (female only) . . . 10% 14% 10%Smoke cessation advice to smokers . . . 46% 55% 45%Primary PTCA 56 . 3326 . 355 13681ASA 55 98% . 90% 95% 90%Beta blocker 45 80% . 73% 83% 76%ACE inhibitor 41 73% . 41% 55% 43%Lipid lowering agent 29 52% . 45% 59% 47%Female HRT (female only) 2 13% . 12% 20% 12%Smoke cessation advice to smokers . 33% . 48% 64% 48%No initial reperfusion 172 . . . . .ASA 151 88% . 78% 80% 74%Beta blocker 139 81% . 58% 66% 58%ACE inhibitor 97 56% . 38% 45% 40%Lipid lowering agent 90 52% . 32% 37% 29%Female HRT (female) 8 12% . 9% 11% 7%Smoke cessation advice to smokers . 26% . 40% 48% 36%Primary PTCA, St Cloud Direct Admission, 1999.
SCH
(56) Like Hospital
(3326) MN
(355) Nation
(13681)INTERVENTION .Primary PTCA (All) 56/261 21% . 15% . .Primary PTCA w/o stent 5/56 9% . 19% 10% 17%Primary PTCA with stent 51/56 91% . 71% 76% 73%IV thrombolysis and primary PTCA 0 0% . 3% 0% 3%IC thrombolysis 0 0% . 0.4% 0% <1%Immediate CABG 0 0% . 4% 4% 5%Spontaneous reperfusion . . . 2% 1% 2%Sx to door (median minutes) 109 . 90 . 95 93Door to data 8 . 7 . 7 7Data to dilatation 65 . 101 . 80 96Door to dilation (median minutes) (a) 73 . 108 . 85 104- From 7 am to 3 pm (22) 68 . . . . 97- From 3 pm to 11 pm (11) 68 . . . . 107- From 11pm to 7 am (8) 102 . . . . 120- Weekday (27) 68 . . . . 99- Weekend (14) 102 . . . . 117Door to dilatation <90 min . 65% . 34% 56% 34%(a) Patients with no chest pain at presentation has longer door to dilatation time.
(b) In parenthesis represents number of patients.Back to top
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Primary PTCA, St Cloud Hospital Admission, 1999. (continue)
SCH
(56) Like Hospital
(6133) MN
(325) Nation
(12093)MEDICATIONS RECEIVED WITHIN 24 HOURS .ASA 55 98% . 92% 96% 91%Beta blocker 38 68% . 56% 69% 58%ACE inhibitor 18 32% . 19% 30% 20%IIb/IIIa inhibitor 52 93% . 67% 76% 67%Heparin 39 70% (a) . 91% 89% 91%Calcium channel blocker 1 2% . 9% 15% 8%CLINICAL EVENTS .Free of adverse outcome 49 88% . 56% 54% 56%Recurrent MI 1 2% . 1% 1% 1%Major bleeding 0 0% . 4.7% 4.8% 4.6%Stroke 0 0% . 0.5% 0.8% 0.7%IC hemorrhage 0 0% . 0.1% 0% 0.1%Thromboembolic 0 0% . 0.6% 0.6% o.5%Length of stay (median days) 3.8 . 4.1 . 4.1 4.0Death 0/56 0% . 5.7% 5.9% 6.0%DISCHARGED MEDICATIONS/ THERAPIES .ASA 55 98% . 90% 95% 90%Beta blodker 45 80% . 73% 83% 76%ACE inhibitor 41 73% . 41% 55% 43%Female HRT (female only) (2) (13)% . (12%) (20%) (12%)Lipid lowering agent 29 52% . 45% 59% 47%Smoke cessation advice to smokers 6/18 33% . 48% 64% 48%(a) Patients undergoing primary PTCA who recieved GPIIbIIIa were not included.
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Transfer-In, 1999.
(a), (b) SCH
(274/535)
(51%)
(>22 of 1st Hosp) Like Hospital
(11860/32820 )
(36%) MN
(1336)
(>80 Centers) Nation
(46531)
(>4856 Centers)THROMBOLYSIS AT 1st HOSPITAL 83/274 30% (c) . . 26% 27%Sx to 1st hospital door (median minutes) 93 . 85 . 80 851st hospital door to drug 40 . 37 . 34 351st hospital door to drut < 30 minutes . 38% . 40% 46% 41%Sx onset to drug 144 . 131 . 121 131INITIATED AT REGISTRY HOSPITAL 0 . . 1% 0 2%Sx onset to 1st hospital door NA . 110 . N/A 1091st hospital door to registry hospital door NA . 180 . N/A 171Registry hospital door to drug NA . 46 . N/A 50Registry hospital door to drug < 30 minutes 0% . . 30% 0% 31%Sx onset to drug at registry hospital NA . 302 . N/A 324LENGTH OF STAY AND CLINICAL EVENTS (d), (e) .Days at 1st hospital
(days - median, mean) 0.5, 1.0 . 0.5, 1.1 . 0.6, 1.2 0.5, 1.2Days at registry hospital, all patients 4.3, 6.0 . 4.1, 5.7 . 3.9, 5.6 4.0, 5.6Total days at 1st and registry hospital 5.1, 7.0 . 5.2, 6.9 . 4.9, 6.7 5.2, 6.8Death at registry hospital 20 7.3% . 5.8% 6.1% 6.3%(a) Range: (1) Sx onset to 1st Hospital door (initiated at 1st or Registry Hospital) = 0 to 4320 minutes (72 hours). (2) 1st Hospital door to drug (initiated at 1st Hospital of Registry Hospital) = 0 - 1440 minutes (24 houra). (3) Sx onset to drug (initiated at 1st or Registry Hospital) = 0 - 1440 minutes (24 hours). (4) 1st Hospital door to Registry door = 0 to 10 days. (b) Patients excluded from analysis: (1) Prehospital thrombolysis admistration. (2) MI Sx onset after 1st Hospital arrival. (3) No ST elevation and/or LBBB on 1st 12-lead ECG results. (4) any interval with a missing value. (c) Include patients did not meet standard initial reperfusion criteria.
(d) 0.1 day = 2.4 hours. (e) Range: (1) Length of stay at 1st Hospital = 0 to 10 days. (2) Length of stay at Registry Hospital = 0 to 365 days. (3) Total, 1st and Registry Hospital = 0 to 365 days.Back to top
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Transfer-In, 1999. (continue)
SCH
(274/535)
(51%)
(>22 of 1st Hosp) Like Hospital
(11860/32820)
(36%) MN
(1336)
(>80 Centers) Nation
(46531)
(>4856 Centers)MEDICATIONS RECEIVED WITHIN 24 HOURS . ASA 267 97% . 83% 95% 85%Beta blocker 201 73% . 56% 69% 58%ACE inhibitor 105 38% . 20% 27% 20%IIb/IIIa 28 10% . 17% 18% 18%Heparin 225 82% . 85% 91% 86%Calcium channel blocker 28 10% . 17% 12% 10%DISCHARGED MEDICATIONS/ THERAPIES FROM REGISTRY HOSPITAL .ASA 241 97% . 89% 91% 88%Beta blocker 215 87% . 69% 78% 69%ACE inhibitor 151 61% . 37% 46% 39%Female HRT (female only) 14 17% . 12% 18% 12%Lipid lowering agent 155 63% . 43% 50% 43%Smoke cessation advice to smokers 25/69 36% . 43% 55% 46%PROCEDURES PERFORMED PRIOR TO DISCHARGE (a) .Coronary angiography (b) . 72% . 50% 42% 50%PTCA without stent (c) . 2% . 5% 4% 5%PTCA with stent (d) . 33% . 42% 44% 38%CABG . 15% . 23% 13% 20%IIb/IIIa IV > 24 hours . 14% . 13% 17% 15%IABP . 4% . 8% 8% 7%Echocardiography . 49% . 29% 45% 31%Stress test . 22% . 5% 11% 6%(a) Patients receiving multiple procedures of the same category are only count once.
(b) Coronary angiography should be marked when this procedure is performed alone and not in conjunction with an initial reperfusion strategy.
(c) PTCA without stent (excluding Primary PTCA) = elective PTCA without stent and/or rescue PTCA without stent.
(d) PTCA with stent (excluding Primary PTCA) = elective PTCA with stent and/or rescue PTCA with stent.Back to top
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Primary PTCA, Transfer-In, 1999.
Number of patients at SCH is small. Statistical analysis may be invalid.
SCH
(10/274)
(>22 of 1st Hosp) Like Hospital
MN
Nation
(2628/ 46531)
(>4856 Centers)DERMOGRAPHIC . Male 9/10 90% . . . 68%Female . 10% . . . 32%Age (mean years) 60 . . . . 62- Male 58 . . . . 60- Female 79 . . . . 66CLINICAL PRESENTATION .No CHF (Killip 1) 9 90% . . . 82%Rales, JVD (Killip 2) . 10% . . . 7%Pulmonary edama (Killip 3) . 0% . . . 2%Cardiogenic shock (Killip 4) . 0% . . . 5%LENGTH OF STAY AND CLINICAL EVENTS .Days at 1st Hospital
(days -median,mean) 0.2, 0.4 . . . . 0.1, 0.3Days at Registry Hospital, all patients 3.9, 3.8 . . . . 3.6, 4.9Total days at 1st and Registry Hospital 4.3, 4.0 . . . . 3.8, 5.1Death at Registry Hospital 0% . . . . 7%Back to top
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Primary PTCA, Transfer-In, 1999. (continue)
Number of patients at SCH is small. Statistical analysis may be invalid.
SCH
(10/274)
(>22 of 1st Hosp) Like Hospital
MN
Nation
(2628/ 46531)
(>4856 Centers)MEDICATIONS RECEIVED WITHIN 24 HOURS OF MI Dx . ASA 10 100% . . . 89%Beta blocker (oral or IV) . 90% . . . 58%ACE inhibitor . 50% . . . 20%IIb/IIIa . 70% . . . 64%Heparin (including LMWH) . 100% . . . 91%Calcium channel blocker . 10% . . . 9%DISCHARGED MEDICATIONS/ THERAPIES (from Registry Hospital) .ASA . 100% . . . 90%Beta blocker . 90% . . . 75%ACE inibitor . 60% . . . 45%Female HRT (female only) . 0% . . . 13%Lipid lowering agent . 50% . . . 45%Smoking cessation advice to smokers . 40% . . . 50%PRIMARY PTCA PATIENTS Receiving Procedures Prior to Discharge .Subsequent coronary angiography . 0% . . . 23%Elective PTCA without stent . 0% . . . 1%Elective PTCA with stent . 0% . . . 5%CABG (excluding immediate) . 0% . . . 6%IV IIb/IIIa inhibitor >24 hrs . 0% . . . 5%IABP . 0% . . . 15%Echocardiography . 70% . . . 37%Stress test . 10% . . . 3%