ARBs (Those in Heart Failure Trials)

ARB
Initial Dose
Target Dose
FDA approved
Losartan (Cozaar) (1)
25 mg qd
50 qd  (4)
No
Valsartan (Diovan) (2)
80 mg qd
160 mg bid
Yes
Irbesartan (Avapro)
75 mg qd
150 - 300 qd  (5)
No
Candesartan (Atacan) (3)
4 mg qd
32 mg qd
Yes

(1) In ELETE II, 2000.  (2) In Val-Helf, 2001 and VALIANT, 2003.  (3) In CHARM, 2003.  (4) Dose of 100 mg qd may be better.  (5) Need to be confirmed.

ARBs (Those in Heart Failure Trials) - Drug Formulary and Pricing

Brand Name
Generic
Medica
(2002)

BCBS
(2002)
UCare
(2002)
Pref
One
(2002)
Health
Partner
(2002)
Mayo
(2002)
Aetna
(2002)
PCS
(2002)
Dose/Day
(mg)
(a)
Cost/30 Days
($)
Cozaar
Losartan
Y
.
Y
Y
.
Y
Y
Y
50/day
41.31
Diovam
Valsatan
Y
Y
Y
Y
.
Y
Y
Y
80/day
160/day
40.90
45.97
Avapro
Irbesartan
.
.
Y
Y
Y
.
.
Y
150/day
300/day
44.74
51.56
Atacan
Candesatan
.
Y
.
.
.
Y
.
.
16/day
40.49