Diuretics (oral)

.	Initial dose	Target dose	Maximal dose
Loop Diuretics	.
Furosamide (Lasix)	20-40 mg qd	as needed	240 mg bid (a)
Bumetanide (Bumex)	0.5-1.0 mg qd	as needed	10 mg qd
Torsemide (Demedex)	10-20 mg qd	as needed	80-120 mg bid
Thiazide Diuretics	.
Hydrochlorothiazide	25-50 mg qd	as needed	100-200 mg qd
Thiazide-Related Diuretics	.
Metolazone (Zaroxolyn) (b)	2.5-5.0 mg qd	2.5-5.0 mg 2-3 time/wk	10 mg qd
Potassium Sparing Diuretics	.
Spironolactone	(See Aldosterone Antagonist section)
Triamterene, Amiloride	(Not use in HF)

(a) = oral Furosamide up to 2500 mg/day has been reported without toxicity.
(b) = Metolazone may cause significant electrolyte imbalance.

Diuretics (intravenous, bolus)

.	Dose depending on Creatinine Clearance	Dose Frequency
Furosamide	>40 mg ------ 160-240 mg (a)	q 8 hrs, q 12 hrs
Bumetanide	>2 mg ------	q 12 hrs
Torsemide	10-20 mg ------ 100 mg	q 12 hrs

(a) = bolus Furosemide up to 1000 mg has been reported.

Diuretics (intravenous, infusion)

.	Loading Dose (mg)	Infusion Rate (mg/hr)
		CrCl >75 ml/min	CrCl 25-75 ml/min	CrCl <25 ml/min
Furosamide (a)	40	10	10-20	20-40
Bumetanide	1	0.5	0.5-1	1-2
Torsemide	20	5	5-10	10-20

(a) = infusion Furosemide up to 4000 mg/day has been reported